CICCR encourages collaboration between industry and not-for-profit organizations by identifying potential leads under investigation in not-for-profit organizations, in both developed and developing countries; encouraging industry to collaborate with and provide support for these organizations; and providing additional funds to investigators at not-for-profit entities. CICCR operates flexibly and on a case-by-case basis to accomplish its goals.

Support for CICCR was initiated by the Rockefeller Foundation. Subsequent support has been provided by the Andrew W. Mellon Foundation, the Bill & Melinda Gates Foundation, the William and Flora Hewlett Foundation, the David and Lucile Packard Foundation, the United Nations Population Fund, and a foundation that wishes to remain anonymous.